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Patel, Nirav
- Formulation and Evaluation of Floating Tablet Containing Glipiz
Abstract Views :210 |
PDF Views:0
Authors
Affiliations
1 Maratha Mandal's College of Pharmacy, Belgaum-590016, Karnataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
1 Maratha Mandal's College of Pharmacy, Belgaum-590016, Karnataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 4 (2012), Pagination: 135-140Abstract
The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like Xanthan Gum, Guar Gum, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2º C with 75±2 RH for 3 months.Keywords
Gatroretentive, Glipizide, Buoyancy Studies, Swelling Studies, Stability Studies.- Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System
Abstract Views :194 |
PDF Views:1
Authors
Affiliations
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 2 (2012), Pagination: 67-73Abstract
The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like HPMC K100M, sodium alginate, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2° C with 75±2 RH for 3 months.Keywords
Glipizide, Gatroretentive, Intragastric Floating Tablets, Buoyancy Studies, Swelling Studies.- Design and Development of Floating Tablet of Glipizide
Abstract Views :201 |
PDF Views:0
Authors
Affiliations
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 260-266Abstract
The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like HPMC K15M, HPMC K100M, sodium alginate, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2° C with 75±2 RH for 3 months.Keywords
Glipizide, Gatroretentive, Intragastric Floating Tablets, Buoyancy Studies, Swelling Studies.- Formulation and Evaluation of Buccal Films of Timolol Maleate
Abstract Views :175 |
PDF Views:0
Authors
Affiliations
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
2 Department of Pharmaceutics, Maratha Mandal’s College of Pharmacy, Belgaum, Karnataka, IN
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
2 Department of Pharmaceutics, Maratha Mandal’s College of Pharmacy, Belgaum, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 177-184Abstract
The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like Xanthan Gum, Guar Gum, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2°C with 75±2 RH for 3 months.Keywords
Gatroretentive, Glipizide, Buoyancy Studies, Swelling Studies, Stability Studies.- Formulation and Evaluation of Floating Tablet of Glipizide Using Different Polymers
Abstract Views :185 |
PDF Views:0
Authors
Affiliations
1 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
2 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
3 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
1 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
2 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka, IN
3 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 185-191Abstract
The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like Xanthan Gum, Guar Gum, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2° C with 75±2 RH for 3 months.Keywords
Gatroretentive, Glipizide, Buoyancy Studies, Swelling Studies, Stability Studies.- Floating Drug Delivery System:An Innovative Acceptable Approach in Gastroretentive Drug Delivery
Abstract Views :209 |
PDF Views:0
Authors
Affiliations
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 2 (2012), Pagination: 93-103Abstract
Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. The recent developments of floating drug delivery systems (FDDS) including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems. Floating dosage form can be prepared as tablets, capsules by adding suitable ingredients as well as by adding gas generating agent. In this review various techniques used in floating dosage forms along with current and recent developments of stomach specific floating drug delivery system for gastro retention are discussed.Keywords
Floating Drug Delivery Systems, Mechanism, Single Unit, Multiple Units, Evaluation Method.- Floating Drug Delivery System:An Innovative Acceptable Approach in Gastro Retentive Drug Delivery
Abstract Views :193 |
PDF Views:1
Authors
Affiliations
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN
1 Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karanataka, IN
2 A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat, IN